基础：添加以下引用：1，iisext.dll; 2, adsiis.dll; 3,activeds.tlb。 

1，在 IIS 建立虚拟目录， 

Dim sComputer as string 

Dim websvc, vRoot, vDir 

sComputer = "localhost" 

''Get Default Web Site Object 

Set websvc = GetObject("IIS://" & sComputer & "/W3svc/1") 

''Get root of Default Web Site 

Set vRoot = websvc.GetObject("IIsWebVirtualDir", "Root") 

Dim itm As ListItem 

Dim buf As String, errInfo As String, tryVirt 

For Each itm In ListView1.ListItems 

Err.Clear 

On Error Resume Next 

Set tryVirt = GetObject("IIS://" & sComputer & "/W3svc/1/ROOT/" & itm.SubItems(1)) 

''Debug.Print Err.Number 

''如果得不到对应的虚拟目录，则出错，此时可以新建此虚拟目录。 

If Err.Number <> 0 Then 

Err.Clear 

Set vDir = vRoot.Create("IISWebVirtualDir", itm.SubItems(1)) 

vDir.path = itm.Text 

vDir.Accessread = True 

vDir.SetInfo 

Else 

''记录已经创建的虚拟目录名称。 

''If tryVirt.AppGetStatus2 = 0 Then 

errInfo = errInfo & vbCrLf & itm.SubItems(1) 

End If 

Next 

其实就是 

Set websvc = GetObject("IIS://" & sComputer & "/W3svc/1") 

Set vRoot = websvc.GetObject("IIsWebVirtualDir", "Root") 

Set vDir = vRoot.Create("IISWebVirtualDir", vdName) 

vDir.Path=someDir 

vDir.setInfo 

这几个语句就够了 

2。删除虚拟目录 

Dim sComputer, sPhyDir, sVirDir As String 

Dim websvc, vRoot, vDir 

sComputer = "localhost" 

''Get Default Web Site Object 

Set websvc = GetObject("IIS://" & sComputer & "/W3svc/1") 

''Get root of Default Web Site 

Set vRoot = websvc.GetObject("IIsWebVirtualDir", "Root") 

Dim itm As ListItem 

Dim buf As String, errInfo As String, tryVirt 

For Each itm In ListView1.ListItems 

Err.Clear 

On Error Resume Next 

Call vRoot.Delete("IISWebVirtualDir", itm.SubItems(1)) 

If Err.Number <> 0 Then 

errInfo = errInfo & vbCrLf & itm.SubItems(1) 

End If 

Err.Clear 

Next